Drug interaction advice? Posted on March 13, 2013 gregskoogPosted in Uncategorized So if i take a probiotic and an antibiotic at the same time, am I going to tear a hole in the fabric of our universe? Is this, like, crossing-the-streams bad? Am I mixing a matter and anti-matter cocktail here? Just to be safe, I’m going to throw down a couple Tylenol too. That should cover things.